The mechanism of phospholipase C-γ1 regulation
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چکیده
منابع مشابه
Parkin-mediated ubiquitination regulates phospholipase C-γ1
Mutations in parkin cause autosomal recessive forms of Parkinson's disease (PD), with an early age of onset and similar pathological phenotype to the idiopathic disease. Parkin has been identified as an E3 ubiquitin ligase that mediates different types of ubiquitination, which has made the search for substrates an intriguing possibility to identify pathological mechanisms linked to PD. In this ...
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A body of evidence, linking inositide-specific phospholipase C (PI-PLC) to the nucleus, is quite extensive. The main isoform in the nucleus is PI-PLCbeta1, whose activity is up-regulated in response to insulin-like growth factor-1 (IGF-1) or insulin stimulation. Whilst at the plasma membrane this PI-PLC is activated and regulated by Galphaq/alpha(11) and Gbetagamma subunits, there is yet no evi...
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The receptors involved in the regulation of phospholipase C by hormones, neurotransmitters and other ligands have seven transmembrane-spanning hydrophobic regions (seven-helix motif) and no known enzymatic activity. Furthermore these receptors can be isolated as complexes with guanine nucleotide binding (G) proteins. Guanine nucleotides affect the binding of hormones that stimulate phospholipas...
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Wang Y, Tomar A, George SP, Khurana S. Obligatory role for phospholipase C1 in villin-induced epithelial cell migration. Am J Physiol Cell Physiol 292: C1775–C1786, 2007. First published January 17, 2007; doi:10.1152/ajpcell.00420.2006.—While there is circumstantial evidence to suggest a requirement for phospholipase C1 (PLC1) in actin reorganization and cell migration, few studies have examine...
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The role of early secretory trafficking in the regulation of cell motility remains incompletely understood. Here we used a small interfering RNA screen to monitor the effects on structure of the Golgi apparatus and cell migration. Two major Golgi phenotypes were observed-fragmented and small Golgi. The latter exhibited a stronger correlation with a defect in cell migration. Among the small Golg...
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ژورنال
عنوان ژورنال: Experimental & Molecular Medicine
سال: 2000
ISSN: 2092-6413
DOI: 10.1038/emm.2000.18